Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2

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Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2

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作者：Mingze Su ; Kuanhui Xiang ; Yao Li ; Yutang Li ; Juan Deng ; Xizhan Xu ; Ling Yan ; Hui Zhuang ; ^{zhuangbmu@126.com" class="auth_mail" title="E-mail the corresponding author} ; Tong Li ; ^{tongli08@vip.sina.com" class="auth_mail" title="E-mail the corresponding author}
关键词：AA ; amino acid ; ADV ; adefovir dipivoxil ; CHB ; chronic hepatitis B ; HBeAg ; hepatitis B e antigen ; HBsAg ; hepatitis B surface antigen ; HBV ; hepatitis B virus ; HIV ; human immunodeficiency virus ; HSPGs ; highly sulfated heparan sulfate proteoglycans ; LdT ; telbivudine ; LMV ; lamivudine ; MHR ; major hydrophilic region ; NAs ; nucleos(t)ide analogs ; NAr ; nucleos(t)ide analog resistance ; RT ; reverse transcriptase ; S ; surface
刊名：Infection, Genetics and Evolution
出版年：2016
出版时间：June 2016
年：2016
卷：40
期：Complete
页码：275-281
全文大小：865 K

文摘

•: Mutation analysis was performed in subgenotype B2 HBV RT/S sequences of CHB patients.
•: 49.7% of RT and 33.6% of S sequences had substitutions at 74 studied AA sites.
•: The rtN134D/S (30.8%) and sT126A/S (15.4%) were most frequently detected.
•: RT/S substitutions were associated with lower serum HBV DNA and HBsAg levels.
•: HBsAg level was negatively associated with S protein sequence substitution rate.