Epithelial-mesenchymal-transition regulators in prostate cancer: Androgens and beyond

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• 作者：Mary Nakazawa ; Natasha Kyprianou ; ^{nkypr2@uky.edu}
• 关键词：ADT ; Androgen deprivation therapy ; AR ; Androgen receptor ; CRPC ; Castration resistant prostate cancer ; DHT ; Dihydrotestosterone ; EGF ; Epidermal growth factor ; EMT ; Epithelial mesenchymal transition ; ERβ ; Estrogen receptor β ; FGF ; Fibroblast growth factor ; IGF ; Insulin-like growth factor ; MET ; Mesenchymal epithelial transition ; PDGF ; Platelet derived growth factor ; PI3 K ; Phosphatidylinositol 3-OH kinase ; PTEN ; Phosphatase tensin homolog ; RTK ; Receptor tyrosine kinase ; SHH ; Sonic Hedgehog ; TGFβ ; T
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：84-90
• 全文大小：840 K
• 卷排序：166

文摘

Current understanding of EMT as a critical contributor to prostate cancer progression to metastasis and clinical management of the disease. Dissection of the androgen receptor (AR) mechanisms driving therapeutic resistance of prostate tumors to taxane chemotherapy via promoting EMT. Evidence on the transition to a dedifferentiated invasive phenotype mediated by TGFβ and supported by engaging signaling pathways towards reversal of EMT to MET. Elucidation of therapeutic targeting value of EMT signaling, including repression of transcription factors navigating EMT to MET interconversions.