Lesions of the periaqueductal gray disrupt input to the rostral ventromedial medulla following microinjections of morphine into the medial or basolateral nuclei of the amygdala

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• 作者：McGaraughty ; Steve ; Farr ; Dawson A. ; Heinricher ; Mary M.
• 关键词：Sensory systems ; Pain modulation ; anatomy and physiology ; Amygdala ; Rostral ventromedial medulla ; Periaqueductal gray ; Opioid
• 刊名：Brain Research
• 出版年：2004
• 出版时间：May 29, 2004
• 年：2004
• 卷：1009
• 期：1-2
• 页码：223-227
• 全文大小：121 K

文摘

Microinjections of morphine into the basolateral (BLa) and medial (MEa) nuclei of the amygdala differentially affect rostral ventromedial medulla (RVM) neuronal activity and nocifensive behaviors. PAG lesions attenuated or blocked the effects of both BLa and MEa morphine on RVM cell activity, and interfered with the behavioral antinociception produced by BLa infusions. These results demonstrate that the influences from both the BLa and MEa to the RVM are relayed via the PAG.