Indoleamine 2,3-dioxygenase regulates T cell activity through Vav1/Rac pathway

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

Indoleamine 2,3-dioxygenase regulates T cell activity through Vav1/Rac pathway

详细信息查看全文

作者：Runmei Li^a ; ^b ; Hui Li^a ; ^b ; Qian Sun^a ; ^b ; Liang Liu^a ; ^b ; Chen Zhang^a ; ^b ; Xiubao Ren^a ; ^b ; ^{rwziyi@yahoo.com}
关键词：HEK293 ; Human Embryonic Kidney 293 cells ; FBS ; Fetal bovine serum ; IDO ; Indoleamine 2 ; 3-dioxygenase ; IL ; interleukin ; PBMCs ; Peripheral blood monouclear cells ; TIL-Ts ; T cells of tumor infiltrating lymphocytes ; TCR ; T cell receptor
刊名：Molecular Immunology
出版年：2017
出版时间：January 2017
年：2017
卷：81
期：Complete
页码：102-107
全文大小：1075 K
卷排序：81

文摘

A negative correlation between IDO and Vav1 was identified in tumor microenvironment. IDO inhibits the expression of Vav1, subsequent Vav1/Rac cascade. IDO suppresses initial TCR signaling.