First-line antiangiogenics for metastatic renal cell carcinoma: A systematic review and network meta-analysis

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First-line antiangiogenics for metastatic renal cell carcinoma: A systematic review and network meta-analysis

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作者：Benoî ; t Rousseau ; MD ; MSc^a ; ^b ; ^c ; ^{benoit.rousseau@aphp.fr" class="auth_mail" title="E-mail the corresponding author} ; ^{ben.rousseau@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Emmanuelle Kempf ; MD ; MSc^a ; Gaelle Desamericq ; PharmD ; PhD^d ; Emilie Boissier ; MD ; MSc^a ; Marie Chaubet-Houdu ; MD^a ; ^b ; Charlotte Joly ; MD^a ; ^b ; Carolina Saldana ; MD ; MSc^a ; ^b ; Helene Boussion ; MD^a ; ^b ; Cindy Neuzillet ; MD ; MSc^a ; ^b ; Isabelle Macquin-Mavier ; MD ; PhD^a ; ^b ; Sté ; phane Oudard ; MD ; PhD^e ; Laurent Salomon ; MD ; PhD^b ; ^f ; Alexandre de la Taille ; MD ; PhD^b ; ^f ; Christophe Tournigand ; MD ; PhD^a ; ^b
关键词：Renal cell carcinoma ; Angiogenesis inhibitors ; Meta-analysis
刊名：Critical Reviews in Oncology and Hematology
出版年：2016
出版时间：November 2016
年：2016
卷：107
期：Complete
页码：44-53
全文大小：906 K

文摘

•: Five antiangiogenic drugs are recommended as initial treatment of metastatic renal cell carcinoma patients.
•: Sunitinib, pazopanib, axitinib and bevacizumab + interferon alpha-2a yield a similar survival benefit but have different safety profiles.
•: These results may provide guidance to optimize treatment choices.

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