Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection

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Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection

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作者：Salvador Iborra¹ ; ² ; ⁹ ; ^{siborra@cnic.es" class="auth_mail" title="E-mail the corresponding author} ; Marí ; a Martí ; nez-Ló ; pez¹ ; ⁹ ; Francisco J. Cueto¹ ; ³ ; Ruth Conde-Garrosa¹ ; Carlos Del Fresno¹ ; Helena M. Izquierdo¹ ; Clare L. Abram⁴ ; Daiki Mori⁵ ; Yolanda Campos-Martí ; n⁶ ; Rosa Marí ; a Reguera⁷ ; Benjamin Kemp⁸ ; Sho Yamasaki⁵ ; Matthew J. Robinson⁸ ; Manuel Soto² ; Clifford A. Lowell⁴ ; David Sancho¹ ; ¹⁰ ; ^{dsancho@cnic.es" class="auth_mail" title="E-mail the corresponding author}
刊名：Immunity
出版年：2016
出版时间：18 October 2016
年：2016
卷：45
期：4
页码：788-801
全文大小：3935 K

文摘

•: Leishmania releases a proteinaceous ligand that binds human and mouse Mincle
•: Clec4e^−/− mice show enhanced immunity with reduced parasite burden and pathology
•: Leishmania inhibits activation and migration of DCs in a Mincle-dependent manner
•: Leishmania shifts Mincle to an inhibitory FcRγ/SHP1 axis in DCs

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