Synthetic lethality within the same pathway is via the induction of replication catastrophe
•
New origin firing and replication stress induced by CHK1 inhibitor reliance on ATR
•
ATR and CHK1 inhibitor combination results in cancer-specific cytotoxicity
•
ATR and CHK1 inhibitor combination could be used broadly across cancer indications
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.