Reduced-Intensity Conditioning Combined with <sup>188</sup>Rhenium Radioimmunotherapy before Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia: The Role of In聽Vivo T Cell Depletion

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Reduced-Intensity Conditioning Combined with ¹⁸⁸Rhenium Radioimmunotherapy before Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia: The Role of In聽Vivo T Cell Depletion

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作者：Sebastian Schneider¹ ; Annette Strumpf² ; Johannes Schetelig¹ ; Gerd Wunderlich² ; Gerhard Ehninger¹ ; Jö ; rg Kotzerke² ; Martin Bornhä ; user¹ ; ³ ; ^{martin.bornhaeuser@uniklinikum-dresden.de" class="auth_mail" title="E-mail the corresponding author}
关键词：Acute myeloid leukemia ; Stem cell transplantation ; Reduced-intensity conditioning ; Alemtuzumab ; Re-188 radioimmunotherapy
刊名：Biology of Blood and Marrow Transplantation
出版年：2015
出版时间：October 2015
年：2015
卷：21
期：10
页码：1754-1760
全文大小：713 K

文摘

•: We combined reduced-intensity conditioning and ¹⁸⁸rhenium anti-CD66 radioimmunotherapy in a prospective phase II trial.
•: 5">Associated with limited extramedullary toxicity in 58 patients with high-risk acute myeloid leukemia/myelodysplastic syndrome.
•: Reduction of Campath-1H from 75 to 50 mg did not improve overall outcome.
•: 5">Further optimization of the current approach is needed.