Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

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Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

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作者：Hind Medyouf¹ ; ¹¹ ; ¹³ ; ^{hind.medyouf@uniklinikum-dresden.de" class="auth_mail} ; Maximilian Mossner² ; Johann-Christoph Jann² ; Florian Nolte² ; Simon Raffel³ ; Carl Herrmann⁴ ; ⁵ ; Amelie Lier³ ; Christian Eisen³ ; Verena Nowak² ; Bettina Zens¹ ; ³ ; Katja Mü ; dder¹ ; ³ ; Corinna Klein¹ ; ³ ; Julia Oblä ; nder² ; Stephanie Fey² ; Jovita Vogler² ; Alice Fabarius² ; Eva Riedl⁶ ; Henning Roehl⁷ ; Alexander Kohlmann⁸ ; Marita Staller⁸ ; Claudia Haferlach⁸ ; Nadine Mü ; ller² ; Thilo John⁹ ; Uwe Platzbecker¹⁰ ; Georgia Metzgeroth² ; Wolf-Karsten Hofmann² ; Andreas Trumpp¹ ; ³ ; ¹¹ ; ¹² ; ^{a.trumpp@dkfz-heidelberg.de" class="auth_mail} ; ^{andreas.trumpp@hi-stem.de" class="auth_mail} ; Daniel Nowak² ; ¹²
刊名：Cell Stem Cell
出版年：5 June 2014
年：2014
卷：14
期：6
页码：824-837
全文大小：4466 K

文摘

•: Disease-initiating cells in lower-risk MDS are restricted to Lin⁻CD34⁺CD38⁻ subset
•: Myelodysplastic cells in patients reprogram mesenchymal stromal cells
•: Reprogrammed MSCs are essential for propagation of myelodysplastic syndromes
•: MDS and niche cells interact via bidirectional signaling crosstalk

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