Persistent detection of a novel MLL–SACM1L rearrangement in the absence of leukemia

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• 作者：Takeshi Mori ; Noriyuki Nishimura ; Daiichiro Hasegawa ; Keiichiro Kawasaki ; Yoshiyuki Kosaka ; Kazuko Uchide ; Tomoko Yanai ; Akira Hayakawa ; Yasuhiro Takeshima ; Hisahide Nishio ; Masafumi Matsuo
• 关键词：Acute lymphoblastic leukemia ; Chemotherapy ; MLL ; SACM1L
• 刊名：Leukemia Research
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：34
• 期：10
• 页码：1398-1401
• 全文大小：303 K

文摘

Most chromosomal rearrangements including the mixed lineage leukemia (MLL) gene are manifested as leukemia and predict a poor prognosis. Although more than 50 MLL-rearrangement partners are characterized, MLL-related leukemogenesis remains to be understood. Here we report a case of a 3-year old boy bearing a novel MLL-rearrangement with the suppressor of actin mutations 1-like (SACM1L) gene in the absence of leukemia. Bone marrow cells harboring the MLL–SACM1L rearrangement appeared during chemotherapy for acute lymphoblastic leukemia with hyperdiploidy and were continuously detected over 7 years without clonal expansion.