Evaluation of route-to-route extrapolation factors based on assessment of repeated dose toxicity studies compiled in the database RepDose<sup>®sup>
文摘
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d="par0005">R2R extrapolation factors (oral-to-dermal and oral-to-inhalation) are derived based on no/lowest effect levels (NOELs/LOELs) in the Fraunhofer RepDose<sup>®sup> database.

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d="par0010">R2R extrapolation oral-to-inhalation: the analysis is based on a big dataset consisting of 246 study pairs on 110 chemicals.

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d="par0015">Extrapolation factors and associated uncertainties are evaluated.

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d="par0020">An EF of 3 for the extrapolation oral-to-inhalation is proposed. It covers also the uncertainty that unexpected local effects may occur in an inhalation study.

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