Homology Requirements and Competition between Gene Conversion and Break-Induced Replication during Double-Strand Break Repair

详细信息    查看全文

• 作者：Anuja Mehta¹ ; Annette Beach¹ ; James E. Haber¹ ; ² ; ^{haber@brandeis.edu}
• 关键词：homologous recombination ; budding yeast ; strand invasion ; homology search ; recombination enhancer ; Sgs1(BLM) ; Mph1(FANCM) ; Pol32 ; Pif1
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：515-526.e3
• 全文大小：1540 K
• 卷排序：65

文摘

Tethering an inefficient donor near a DSB rescues repair efficiency Capture of the second DSB end is inefficient when homology at the second end is ≤150 bp Reduced homology at the second end shifts repair from gene conversion to BIR Sgs1 and Mph1 helicases promote opposing repair pathways in these strains