Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation

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• 作者：Sharmistha Kundu¹ ; ² ; Fei Ji¹ ; ² ; Hongjae Sunwoo¹ ; ² ; Gaurav Jain⁵ ; Jeannie T. Lee¹ ; ² ; ³ ; ⁴ ; Ruslan I. Sadreyev¹ ; ³ ; Job Dekker⁴ ; ⁵ ; Robert E. Kingston¹ ; ² ; ⁶ ; ^{kingston@molbio.mgh.harvard.edu}
• 关键词：Polycomb ; PRC1 ; compaction ; chromatin ; 5C ; STORM ; higher-order structure ; cell fate ; differentiation
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：432-446.e5
• 全文大小：8791 K
• 卷排序：65

文摘

PRC1-repressed loci form isolated self-interacting domains of compacted chromatin Decompaction of developmentally regulated loci follows PRC1 loss upon differentiation Chromatin compaction requires canonical PRC1, but not variant PRC1 or H2AK119Ub PRC1-associated domains are distinct from topologically associated domains