CD32b expression is down-regulated on double-negative memory B cells in patients with Hashimoto's thyroiditis

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• 作者：Yalei Liu^a ; ^{liuyalei88@163.com} ; Yan Gong^b ; ^{gongyan2001@126.com} ; Chenxue Qu^b ; ^{qucx2012@163.com} ; Yang Zhang^a ; ^{emilyzy14@sina.com} ; Ran You^b ; ^{youran829@126.com} ; Nan Yu^a ; ^{yunan_7936@sina.com} ; Guizhi Lu^a ; ^{luguizhi64@sina.com} ; Youyuan Huang^a ; ^{huangyouyuan1905@163.com} ; Hong Zhang^a ; ^{yamuzhang0229@163.com} ; Ying Gao^a ; ^{gaoyingendo@sina.com} ; Yanming Gao^a ; ^{bdyygaoyanming@sina.com} ; Xiaohui Guo^a ; ^{guoxh@medmail.com.cn}
• 关键词：Hashimoto's thyroiditis ; B cell subsets ; Double-negative memory B cells ; CD32b
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：440
• 期：Complete
• 页码：1-7
• 全文大小：1128 K
• 卷排序：440

文摘

The percentage of double-negative memory B cells was increased in HT patients. The expression level of CD32b was decreased in HT patients. B cell subset distribution was regulated by B cell receptor stimulation. CD32b down-regulation was mediated by the CD40-CD40L pathway.