Molecular mechanism of endocrine system impairment by 17α-methyltestosterone in gynogenic Pengze crucian carp offspring

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Molecular mechanism of endocrine system impairment by 17α-methyltestosterone in gynogenic Pengze crucian carp offspring

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作者：Yao Zheng^a ; ^b ; ^c ; ^d ; ^e ; Jiazhang Chen^b ; ^c ; ^d ; Yan Liu^a ; Jiancao Gao^a ; Yanping Yang^a ; ^b ; ^c ; ^d ; Yingying Zhang^a ; Xuwen Bing^b ; ^c ; ^d ; Zexia Gao^e ; Hongwei Liang^f ; Zaizhao Wang^a ; ^{zzwang@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：17α-methyltestosterone ; Estrogen signalling ; Gynogenic Pengze crucian carp ; Steroid hormones ; Steroidogenesis ; Vitellogenesis
刊名：Ecotoxicology and Environmental Safety
出版年：2016
出版时间：June 2016
年：2016
卷：128
期：Complete
页码：143-152
全文大小：4253 K

文摘

•: Partial cDNAs of five steroidogenic genes of gynogenic fish were obtained.
•: The steroid hormones (11-KT, T and E2) balance was disrupted following MT exposures.
•: Ovarian and hepatic vitellogenesis showed significant increments.
•: Some morphological indicators were altered and oocyte cell development was repressed.

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