Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats

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• 作者：Xiaohong Zhao ; Lei Sun ; Hongxiao Jia ; Qingxuan Meng ; Si Wu ; Nanxin Li ; Shuchang He
• 关键词：Anxiety ; Glutamate ; Neurodevelopmental-related gene ; Social isolation ; Social recognition
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2009
• 出版时间：1 October 2009
• 年：2009
• 卷：33
• 期：7
• 页码：1173-1177
• 全文大小：259 K

文摘

Isolation rearing induces various cognitive abnormalities such as reversal learning deficits and reduced prepulse inhibition in rats. However, there are few reports in the literature on its effects on social and emotional functions. In the current study we aimed to address these issues and demonstrated that isolation rearing induced aggression and impaired social recognition, produced moderate anxiogenic effects in the elevated-plus maze, and resulted in hyperactivity in a novel open field. We also found NR2A, NR2B, PSD-95 and SAP-102 mRNA expression were significantly up-regulated in the hippocampus while NR2B was down-regulated in prefrontal cortex in response to isolation rearing. This study advances the use of social isolation as an animal model for studying etiological mechanisms of various neuropsychiatric disorders.