NOTCH1 intracellular domain negatively regulates PAK1 signaling pathway through direct interaction

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NOTCH1 intracellular domain negatively regulates PAK1 signaling pathway through direct interaction

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作者：Ji-Hye Yoon^a ; Jung-Soon Mo^a ; Eun-Jung Ann^a ; Ji-Seon Ahn^a ; Eun-Hye Jo^a ; Hye-Jin Lee^a ; Se-Hoon Hong^a ; Mi-Yeon Kim^a ; Eung-Gook Kim^b ; Keesook Lee^a ; Hee-Sae Park^a ; ^{proteome@jnu.ac.kr" class="auth_mail" title="E-mail the corresponding author}
关键词：NOTCH1-IC ; NOTCH1 intracellular domain ; PAK1 ; p21-activated kinase 1 ; ILK1 ; integrin-linked kinase 1
刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
出版年：2016
出版时间：February 2016
年：2016
卷：1863
期：2
页码：179-188
全文大小：1531 K

文摘

•: NOTCH1-IC physically interacts with PAK1 in intact cells.
•: NOTCH1-IC regulates PAK1-mediated ILK1 signaling pathway.
•: NOTCH1-IC disrupts the interaction between PAK1 and ILK1 by interacting with PAK1.
•: NOTCH1-IC alters the localization of PAK1 and inhibits PAK1-mediated cell migration.

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