APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication

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APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication

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作者：James I. Hoopes¹ ; ³ ; Luis M. Cortez¹ ; ³ ; Tony M. Mertz¹ ; Ewa P. Malc² ; Piotr A. Mieczkowski² ; Steven A. Roberts¹ ; ^{sroberts@vetmed.wsu.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：16 February 2016
年：2016
卷：14
期：6
页码：1273-1282
全文大小：2112 K

文摘

class="label">•: APOBEC3A and APOBEC3B deaminate ssDNA formed during DNA lagging strand synthesis in yeast
class="label">•: A3A and A3B deaminate lagging strand ssDNA more commonly than transcription bubbles
class="label">•: Replication stress and loss of replisome integrity increase APOBEC mutagenesis
class="label">•: Extensive DNA synthesis may produce substrates for APOBEC editing of cancer genomes

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