A Single Legionella Effector Catalyzes a Multistep Ubiquitination Pathway to Rearrange Tubular Endoplasmic Reticulum for Replication

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• 作者：Kristin M. Kotewicz¹ ; ⁶ ; Vinay Ramabhadran¹ ; ³ ; ⁶ ; Nicole Sjoblom² ; Joseph P. Vogel⁴ ; Eva Haenssler¹ ; ⁷ ; Mengyun Zhang¹ ; Jessica Behringer⁵ ; Rebecca A. Scheck² ; Ralph R. Isberg¹ ; ³ ; ⁸ ; ^{ralph.isberg@tufts.edu}
• 关键词：Legionella pneumophila ; ubiquitin ; reticulon ; endoplasmic reticulum ; ADP-ribosylation ; nucleotidase ; transferase ; phosphodiesterase ; replication vacuole formation ; type IV secretion ; Sde proteins
• 刊名：Cell Host & Microbe
• 出版年：2017
• 出版时间：8 February 2017
• 年：2017
• 卷：21
• 期：2
• 页码：169-181
• 全文大小：4439 K
• 卷排序：21

文摘

Legionella Sde proteins remodel tubular ER to initiate intracellular replication The tubular ER protein reticulon 4 is targeted by Sde proteins ER remodeling requires ubiquitin transfer by Sde proteins Ubiquitin transfer involves ADP-ribosyltransferase and nucleotidase activities