Mutations in human immunodeficiency virus type 1 reverse transcriptase that make it sensitive to degradation by the viral protease in virions are selected against in patients
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文摘
1.

Mutations in several subdomains of HIV-1 RT lead to degradation by PR in virions.

2.

PR degradation of the mutant RTs is temperature sensitive in virions and in E. coli.

3.

The replication of viruses that carry the RT mutations is temperature sensitive.

4.

The PR-sensitive mutations are seen only rarely in the Stanford Database.

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