Phase transfer-catalyzed synthesis of highly acrylated hyaluronan

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• 作者：Jana Becher ; Stephanie Mö ; ller ; Matthias Schnabelrauch ; ^{ms@innovent-jena.de}
• 关键词：Hyaluronan ; Degradation ; Low molecular weight ; Hydrogel ; Acrylate ; Photo-cross-linking
• 刊名：Carbohydrate Polymers
• 出版年：2013
• 出版时间：2 April, 2013
• 年：2013
• 卷：93
• 期：2
• 页码：438-441
• 全文大小：393 K

文摘

Glycosaminoglycans and its derivatives have gained increasing attention for the fabrication of hydrogels usable in biomedicine. Starting from high molecular weight hyaluronan, a natural glycosaminoglycan that forms a mayor component of the native extracellular matrix, we present an efficient phase-transfer-based synthesis for low molecular weight hyaluronan acrylates with a tailored degree of substitution (DS) ranging up to DS values of 1.7. The ability of these compounds to form dimensionally stable hydrogels was proven using different photo-initiator systems.