In-vivo evidence that high mobility group box 1 exerts deleterious effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and Parkinson's disease which can be attenuated by glycyrrhizin

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In-vivo evidence that high mobility group box 1 exerts deleterious effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and Parkinson's disease which can be attenuated by glycyrrhizin

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作者：Matteo Santoro^a ; ¹ ; Walter Maetzler^b ; ^c ; ¹ ; Petros Stathakos^a ; Heather L. Martin^a ; Markus A. Hobert^b ; ^c ; Tim W. Rattay^b ; ^c ; Thomas Gasser^b ; ^c ; John V. Forrester^a ; ^d ; ^e ; Daniela Berg^b ; ^c ; Kevin J. Tracey^f ; Gernot Riedel^a ; Peter Teismann^a ; ^{pteismann@gmx.de" class="auth_mail" title="E-mail the corresponding author}
关键词：COX ; cyclooxygenase ; CSF ; Cerebrospinal fluid ; DOPAC ; 3 ; 4-Dihydroxyphenylacetic acid ; GFAP ; glial fibrillary acidic protein ; H&Y ; Hoehn & Yahr ; HMGB1 ; high-mobility group box 1 ; HVA ; homovanillic acid ; MPP+ ; ; 1-methyl-4-phenylpyridinium ; MPTP ; 1-methyl-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine ; OD ; optical density ; PD ; Parkinson's disease ; RAGE ; receptor for advanced glycation endproducts ; SNpc ; substantia nigra pars compacta ; TH ; tyrosine-hydroxylase ; TNF-α ; tumour necrosis factor-alpha ; Wt ; wil
刊名：Neurobiology of Disease
出版年：2016
出版时间：July 2016
年：2016
卷：91
期：Complete
页码：59-68
全文大小：1910 K

文摘

•: HMGB1 is up-regulated in Parkinson's disease.
•: HMGB1 is translocalized into the cytoplasm after MPTP.
•: Inhibition of HMGB1 protects against MPTP-toxicity.
•: Translocalization of HMGB1 is reduced after inhibition a neutralizing antibody or glycyrrhizin.