Low-frequency and very low-intensity ultrasound decreases blood pressure in hypertensive subjects with type 2 diabetes

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• 作者：Katsunori Nonogaki^a ; ^{katsu@trc.med.tohoku.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; ^{knonogaki-tky@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Tomoe Yamazaki^a ; Mari Murakami^a ; Noriko Satoh^a ; Miki Hazama^a ; Kouji Takeda^b ; Nobuyuki Tsujita^b ; Shuichi Katoh^c ; Nariki Kubota^c
• 关键词：Hypertension ; Type 2 diabetes ; Blood pressure ; A device-based approach ; Ultrasound irradiation ; Forearm
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 July 2016
• 年：2016
• 卷：215
• 期：Complete
• 页码：147-149
• 全文大小：173 K

文摘

Despite lifestyle interventions and various types of anti-hypertension agents, hypertension remains difficult to control in some patients with type 2 diabetes. As a noninvasive device-based approach for the treatment of clinic hypertension, we examined the effects of low-frequency and low-intensity ultrasound (500 or 800 kHz, 25 mW/cm²) applied to the forearm on blood pressure (BP) and pulse rate in Japanese subjects with type 2 diabetes and hypertension.

Methods

We examined the effects of low-frequency and low-intensity ultrasound (500 or 800 kHz, 25 mW/cm²) applied to the forearm on BP, pulse rate, and pulse pressure in 212 Japanese subjects (82 men and 130 women; mean age ± SE, 65 ± 1 years) with type 2 diabetes and hypertension (systolic BP > 140 mmHg). The subjects were treated with anti-hypertension agents.

Results

Systolic and diastolic BP, pulse rate, pulse pressure in the 800-kHz ultrasound treatment group were significantly lower than the baseline values in hypertensive subjects with type 2 diabetes, and lower than those of placebo controls. In addition, systolic and diastolic BP, pulse rate, and pulse pressure in the 500-kHz ultrasound treatment group were significantly lower than the baseline values in hypertensive subjects with type 2 diabetes, and systolic BP, pulse rate, and pulse pressure were significantly lower than those of placebo controls.

Conclusions

Low-frequency (800 kHz or 500 kHz) and low-intensity (25 mW/cm²) ultrasound irradiation to the forearm might have potential usefulness as a therapeutic application for clinic hypertension in subjects with type 2 diabetes.