Improvement of drug delivery by hyperthermia treatment using magnetic cubic cobalt ferrite nanoparticles

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• 作者：Chaitali Dey^a ; ^{chaitalidey29@gmail.com} ; Kaushik Baishya^b ; Arup Ghosh^b ; ^c ; Madhuri Mandal Goswami^b ; ^{madhuri@bose.res.in} ; Ajay Ghosh^d ; Kalyan Mandal^b
• 关键词：Magnetic nanoparticles ; Cobalt ferrite ; Magnetic hyperthermia ; Drug release
• 刊名：Journal of Magnetism and Magnetic Materials
• 出版年：2017
• 出版时间：1 April 2017
• 年：2017
• 卷：427
• 期：Complete
• 页码：168-174
• 全文大小：1401 K
• 卷排序：427

文摘

In this study, we report a novel synthesis method, characterization and application of a new class of ferromagnetic cubic cobalt ferrite magnetic nanoparticles (MNPs) for hyperthermia therapy and temperature triggered drug release. The MNPs are characterized by XRD, TEM, FESEM, AC magnetic hysteresis and VSM. These MNPs were coated with folic acid and loaded with an anticancer drug. The drug release studies were done at two different temperatures (37 °C and 44 °C) with progress of time. It was found that higher release of drug took place at elevated temperature (44 °C). We have developed a temperature sensitive drug delivery system which releases the heat sensitive drug selectively as the particles are heated up under AC magnetic field and controlled release is possible by changing the external AC magnetic field.