Mutual sensitization mechanism and self-degradation property of drug delivery system for in vitro photodynamic therapy

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• 作者：Yi Ding ; Lin Zhou ; ^{zhoulin@njnu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xin Chen ; Qi Wu ; Ziyi Song ; Shaohua Wei ; Jiahong Zhou ; ^{zhoujiahong@njnu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Jian Shen
• 关键词：Hypocrellin A ; Graphene oxide ; TiO2 ; Cancer ; Mutual sensitization ; Self-degradation
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：10 February 2016
• 年：2016
• 卷：498
• 期：1-2
• 页码：335-346
• 全文大小：2789 K

文摘

In this manuscript, a photosensitive anti-cancer drug, hypocrellin A (HA), and TiO₂ nanoparticles were co-loaded on the surface of graphene oxide (GO) as a photosensitive drug delivery system. In vitro studies have demonstrated the active uptake of the system into the mitochondrial of tumor cells. Such system has mutual sensitization mechanism to greatly improve the reactive oxygen species (ROSs) generation ability of the complex by visible light irradiation and, thereby, the strong photodynamic therapy (PDT) efficacy. Furthermore, during such PDT process, GO can be destroyed by the ROSs, which would helpful for the metabolism of this drug delivery system.