Antidiabetic and hypolipidemic activities of Algerian Pistachia lentiscus L. leaves extract in alloxan-induced diabetic rats

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• 作者：A. Cherbal^a ; ^b ; ^{phytopharmaco@yahoo.fr} ; M. Kebieche^b ; E.m. Yilmaz^c ; Z. Aydoğmuş^c ; L. Benzaouia^d ; M. Benguessoum^d ; M. Benkedidah^d ; K. Madani^a
• 关键词：Diabetes ; Pistachia lentiscus L. ; Antidiabetic ; α-Amylase ; Sucrase ; Phenolic compounds
• 刊名：South African Journal of Botany
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：108
• 期：Complete
• 页码：157-162
• 全文大小：618 K
• 卷排序：108

文摘

Oral administration of Pistachia lentiscus L. extract to alloxan-induced diabetic rats caused a significant reduction of glycemia. Diabetic rats treated with P. lentiscus L. extract exhibited a highly significant increase of plasma insulin level which is similar to that obtained with glibenclamid. The treatment with P. lentiscus L. extract significantly decreased and brought back the levels of serum lipids to normal values. The hypoglycemic action of P. lentiscus L. may be mediated by more than one biological mechanism including improvement of insulin secretion and lipid profile, as well as inhibition of carbohydrate hydrolyzing enzymes and enhancement of glucose transport across the cell membrane.