Mucosal tolerance disruption favors disease progression in an extraorbital lacrimal gland excision model of murine dry eye

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Mucosal tolerance disruption favors disease progression in an extraorbital lacrimal gland excision model of murine dry eye

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作者：Mauricio Guzmá ; n ; Irene Keitelman ; Florencia Sabbione ; Anal&iacute ; a S. Trevani ; Mirta N. Giordano ; Jerem&iacute ; as G. Galletti ; ^{jeremiasg@gmx.net" class="auth_mail" title="E-mail the corresponding author}
关键词：Dry eye ; Ocular surface ; Cornea ; Conjunctiva ; Mucosal immunology ; Mucosal tolerance ; Desiccating stress ; Animal models
刊名：Experimental Eye Research
出版年：2016
出版时间：October 2016
年：2016
卷：151
期：Complete
页码：19-22
全文大小：590 K

文摘

•: Lacrimal gland excision leads to disruption of ocular mucosal tolerance in mice.
•: Th1/Th17 T cells are induced towards an exogenous antigen instead of Tregs.
•: Topical NF-κB inhibition prevents this change and reduces corneal epitheliopathy.

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