ATF4 (activating transcription factor 4) from grass carp (Ctenopharyngodon idella) modulates the transcription initiation of GRP78 and GRP94 in CIK cells

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ATF4 (activating transcription factor 4) from grass carp (Ctenopharyngodon idella) modulates the transcription initiation of GRP78 and GRP94 in CIK cells

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作者：Qidi Fan^a ; Huiling Mao^a ; Chuxin Wu^b ; Yong Liu^a ; Yousheng Hu^a ; Bin Zhong^a ; Yichuan Mi^a ; Chengyu Hu^a ; ^{hucy2008@163.com" class="auth_mail} ; ^{hucy2008@21cn.com" class="auth_mail}
关键词：ATF4 ; Glucose-regulated protein ; Transcription initiation ; Endoplasmatic reticulum (ER) stress ; Grass carp
刊名：Fish & Shellfish Immunology
出版年：May 2014
年：2014
卷：38
期：1
页码：140-148
全文大小：1286 K

文摘

•: CiATF4 is significantly increased in CIK cells following 37 °C thermal stress.
•: CiATF4 binds to CiGRP78 and CiGRP94 promoter with high affinity in vitro.
•: CiATF4 is able to activate CiGRP78 or CiGRP94 promoter in vivo.
•: CRE elements are the regulatory element for transcription initiation of CiGRP78.

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