Metabolite identification of bentysrepinine (Y101), a novel anti-HBV agent in rats using a five-step strategy based on a combined workflow with two different platforms of liquid chromatography-tandem mass spectrometry

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• 作者：Huirong Fan^a ; ¹ ; ^{fanhr99@163.com} ; Zhanxing Hu^b ; ¹ ; Ruixing Li^c ; Shiqi Dong^d ; Yuan Gu^e ; Ting Liu^f ; Duanyun Si^e ; Guangyi Liang^b ; Changxiao Liu^e ; ^{liuchangxiao@163.com}
• 关键词：Y101 ; Metabolite ; Identification ; Five-step strategy ; LC-QTRAP-MS/MS ; LC-QTOF-MS/MS
• 刊名：Journal of Chromatography B
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：1040
• 期：Complete
• 页码：118-128
• 全文大小：2711 K
• 卷排序：1040

文摘

This is the first metabolic investigation of Y101. A five-step strategy based on LC-QTRAP-MS/MS and LC-QTOF-MS/MS was successfully applied to identify metabolites of Y101. It is important for a better understanding of metabolic fate of Y101 in rats and may act as a reference for clinical pharmacology.