Are psoriasis and psoriatic arthritis the same disease? The IL-23/IL-17 axis data

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• 作者：Lazaros I. Sakkas ; ^{lsakkas@med.uth.gr} ; Dimitrios P. Bogdanos
• 关键词：Biological ; IL-17 ; IL-23 ; Mouse model ; Pathogenesis ; Psoriasis ; Psoriatic arthritis
• 刊名：Autoimmunity Reviews
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：16
• 期：1
• 页码：10-15
• 全文大小：778 K
• 卷排序：16

文摘

Psoriatic arthritis occurs very frequently in patients with psoriasis. It is not clear whether psoriatic arthritis and psoriasis are two distinct entities or one disease. The IL-23/IL-17 axis plays a pivotal role in both conditions. Differential expression of IL-17 and IL-22 occurs at various sites and may explain arthritis and skin lesions. Biologics neutralizing IL-17A or IL-23/IL-12 are effective therapies for both disease. Psoriatic arthritis and psoriasis may be the same disease.