Unveiling a rhythmic regulatory mode hidden in developmental tissue growth by fluorescence live imaging-based mathematical modeling

详细信息    查看全文

• 作者：Tadahiro Iimura^a ; ^b ; ^c ; ^d ; ^{iimura@m.ehime-u.ac.jp} ; Ji-Won Lee^a
• 关键词：Cell cycle ; Embryo ; Development ; Imaging ; Tissue
• 刊名：Journal of Oral Biosciences
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：59
• 期：1
• 页码：6-11
• 全文大小：958 K
• 卷排序：59

文摘

Fluorescence live imaging and mathematical modeling have been used in biomedical fields as a novel combined approach in the post-genomic era. The combined approach can potentially reveal novel biological functions that would not be uncovered by conventional molecular gain- and loss-of-function approaches.HighlightWe used live imaging-based mathematical modeling and revealed a rhythmic regulatory mode of embryonic tissue development hidden in the stochastic cellular behavior of cell cycle progression.ConclusionThe scope of this review is to describe the experimental and theoretical evidence for cell cycle progression as a stochastic molecular and cellular process. In addition, we elucidate the rhythmic mode of tissue development that endows “biological robustness” for reproducible tissue development. Finally, we discuss the potential of the live imaging-based mathematical approach for understanding pathophysiological development in tissues.