Regioselective aza-Michael addition of azoles to 4-(diphenylphosphoryl)but-3-en-2-one

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• 作者：Maria A. Galkina^a ; Georgy V. Bodrin^a ; Evgenii I. Goryunov^a ; Irina B. Goryunova^a ; Aleksandra S. Sherstneva^a ; Jumakan S. Urmambetova^a ; Natalia G. Kolotyrkina^b ; ^{nkolotyr@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mikhail M. Il&rsquo ; in^a ; Valery K. Brel^a ; Konstantin A. Kochetkov^a ; ^{const@ineos.ac.ru" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Mendeleev Communications
• 出版年：2016
• 出版时间：January-February 2016
• 年：2016
• 卷：26
• 期：1
• 页码：75-76
• 全文大小：205 K

文摘

Aza-Michael reaction of (E)-4-(diphenylphosphoryl)but-3-en-2-one with mono- and bicyclic nitrogen heterocycles proceeds regioselectively in the absence of catalysts to give the corresponding ß-diphenylphosphoryl-b-azahetarylalkanones. Its reaction with imidazole in the presence of chiral organocatalysts affords the corresponding enantiomerically enriched adduct in higher yield.