Systemic Immunity Is Required for Effective Cancer Immunotherapy

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• 作者：Matthew H. Spitzer¹ ; ² ; ³ ; ⁴ ; ⁶ ; ⁸ ; ⁹ ; ^{matthew.spitzer@ucsf.edu} ; Yaron Carmi¹ ; ⁷ ; ⁸ ; Nathan E. Reticker-Flynn¹ ; ⁸ ; Serena S. Kwek⁵ ; Deepthi Madhireddy² ; Maria M. Martins¹ ; Pier Federico Gherardini² ; Tyler R. Prestwood¹ ; Jonathan Chabon¹ ; Sean C. Bendall¹ ; Lawrence Fong⁵ ; ⁶ ; Garry P. Nolan² ; ³ ; ^{gnolan@stanford.edu} ; Edgar G. Engleman¹ ; ³ ; ^{edengleman@stanford.edu}
• 关键词：immunotherapy ; tumor immunology ; cancer immunotherapy ; systems immunology ; mass cytometry ; immune responses ; single-cell analysis ; tumor microenvironment ; secondary lymphoid organs
• 刊名：Cell
• 出版年：2017
• 出版时间：26 January 2017
• 年：2017
• 卷：168
• 期：3
• 页码：487-502.e15
• 全文大小：53507 K
• 卷排序：168

文摘

System-wide models reveal coordinated anti-tumor immunity across the organism Tumor eradication requires immune activation in the periphery Network analysis identifies CD4 T cells sufficient to initiate immune responses PD-L1 upregulation early post-therapy protects distal tumors from systemic immunity