Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone
文摘
•

A cloned genotype 3 HEV (pJE03-1760F/wt) was passaged 10 times in A549 cells.

•

The Passage 10 virus had two non-synonymous and four synonymous mutations.

•

Full-length cDNA clones with a single, two, or all six mutations were constructed.

•

HEV with all six mutations produced 2 logs more virions than did starting virus.

•

Both non-synonymous and synonymous HEV mutations enhanced virus production.

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.