Development of a full-length cDNA-derived enterovirus A71 vaccine candidate using reverse genetics technology

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Development of a full-length cDNA-derived enterovirus A71 vaccine candidate using reverse genetics technology

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作者：Ya-Ting Yang^a ; Yen-Hung Chow^a ; ^b ; Kuang-Nan Hsiao^a ; Kai-Chieh Hu^a ; Jen-Ron Chiang^c ; Suh-Chin Wu^d ; Pele Chong^a ; ^b ; ^d ; Chia-Chyi Liu^a ; ^{010113@nhri.org.tw" class="auth_mail" title="E-mail the corresponding author}
关键词：Enterovirus A71 (EV-A71) ; cDNA-derived virus ; Full-length infectious clone ; Vaccine ; Microcarrier
刊名：Antiviral Research
出版年：2016
出版时间：August 2016
年：2016
卷：132
期：Complete
页码：225-232
全文大小：1348 K

文摘

•: A full-length cDNA-derived EV-A71 vaccine candidate based on vaccine strain E59.
•: The cDNA-derived infectious clone is a valuable method to reduce potential risks.
•: The cDNA-derived EV-A71 viruses show weak pathogenicity in an animal model.

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