Plasminogen activator inhibitor type 1 in platelets induces thrombogenicity by increasing thrombolysis resistance under shear stress in an in-vitro flow chamber model

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Plasminogen activator inhibitor type 1 in platelets induces thrombogenicity by increasing thrombolysis resistance under shear stress in an in-vitro flow chamber model

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作者：Kazuya Hosokawa^a ; Tomoko Ohnishi-Wada^a ; Hisayo Sameshima-Kaneko^a ; Tomoka Nagasato^a ; ^b ; Naoki Miura^c ; Kiyoshi Kikuchi^d ; ^e ; Takehiko Koide^b ; Ikuro Maruyama^b ; Tetsumei Urano^f ; ^{uranot@hama-med.ac.jp" class="auth_mail" title="E-mail the corresponding author}
关键词：AUC30 ; area under the flow pressure curve ; CFT ; clot formation time ; CT ; clotting time ; CTI ; corn trypsin inhibitor ; MCF ; maximum clot firmness ; ML ; maximum lysis ; OT ; occlusion time ; PAI-1 ; plasminogen activator inhibitor type 1 ; ROTEM ; rotational thromboelastometry ; T10 ; time to 10 ; kPa ; TEG ; thromboelastography ; TF ; tissue factor ; t-PA ; tissue plasminogen activator ; u-PA ; urokinase type PA ; WT ; wild-type
刊名：Thrombosis Research
出版年：2016
出版时间：October 2016
年：2016
卷：146
期：Complete
页码：69-75
全文大小：1184 K

文摘

•: Shear rate largely modified thrombolytic efficacy of t-PA.
•: PAI-1 inhibitor enhanced the thrombolytic efficacy of t-PA under arterial shear rate.
•: PAI-1 secreted from platelets appeared to potently regulate arterial thrombolysis.