The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond

详细信息    查看全文

• 作者：Tamara Suprunenko^a ; ^{tsup5163@uni.sydney.edu.au" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Markus J. Hofer^b ; ^{markus.hofer@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author}Author Vitae
• 关键词：OASL ; 2'-5'-oligoadenylate synthetase ; PKR ; double-stranded RNA-dependent protein kinase ; GAS ; gamma-activated site ; HCMV ; human cytomegalovirus ; ISG ; IFN-I-stimulated genes ; IFNAR ; interferon alpha receptor ; IFNGR ; interferon gamma receptor ; IRF ; interferon regulatory factor ; IRF9 ; interferon regulatory factor 9 ; ISGF3 ; interferon stimulated gene factor 3 ; ISRE ; interferon stimulated response element ; IFN ; interferon ; JAK1 ; janus kinase 1 ; LCMV ; lymphocytic choriomeningitis virus ; MS ; multiple
• 刊名：Cytokine & Growth Factor Reviews
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：29
• 期：Complete
• 页码：35-43
• 全文大小：1167 K

文摘

The host response to viral infections relies on tightly regulated and intricate signaling pathways involving type I interferons (IFN-Is). The IFN-Is mediate their antiviral effects predominantly through a signaling factor complex that comprises the transcription factors, interferon regulatory factor 9 (IRF9) and the signal transducers and activators of transcription (STAT) 1 and STAT2. While STAT1 and STAT2 have been studied extensively, the biological significance of IRF9 is only beginning to emerge. Recent studies have revealed a unique role for IRF9 as a conductor of the cellular responses to IFN-Is. Intriguingly, novel roles for IRF9 outside of the antiviral response are also being identified. Thus IRF9 may have a more extensive influence on cellular processes than previously recognized, ranging from antiviral immune responses to oncogenesis and gut homeostasis. In this review, we will focus on the distinct and emerging roles of IRF9 in the antiviral host response and beyond.