The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn

详细信息    查看全文

• 作者：Victoria E. Abraira¹ ; ⁸ ; Emily D. Kuehn¹ ; ² ; ⁸ ; Anda M. Chirila¹ ; Mark W. Springel¹ ; Alexis A. Toliver¹ ; Amanda L. Zimmerman¹ ; Lauren L. Orefice¹ ; Kieran A. Boyle³ ; Ling Bai¹ ; ² ; Bryan J. Song¹ ; Karleena A. Bashista¹ ; Thomas G. O'Neill¹ ; Justin Zhuo¹ ; Connie Tsan¹ ; Jessica Hoynoski¹ ; Michael Rutlin⁴ ; ⁹ ; Laura Kus⁵ ; Vera Niederkofler⁶ ; Masahiko Watanabe⁷ ; Susan M. Dymecki⁶ ; Sacha B. Nelson⁴ ; Nathaniel Heintz⁵ ; David I. Hughes³ ; David D. Ginty¹ ; ¹⁰ ; ^{david_ginty@hms.harvard.edu}
• 关键词：spinal cord interneurons ; low-threshold mechanoreceptors ; somatosensation ; spinal cord dorsal horn ; mouse molecular genetics ; synaptic connectivity
• 刊名：Cell
• 出版年：2017
• 出版时间：12 January 2017
• 年：2017
• 卷：168
• 期：1-2
• 页码：295-310.e19
• 全文大小：11605 K
• 卷排序：168

文摘

Convergent LTMR and cortical inputs define the mechanosensory dorsal horn A dorsal horn molecular-genetic toolbox defines 11 interneuron subtypes Dorsal horn interneurons receive specific patterns of cortical and LTMR inputs Dorsal horn interneurons modulate output pathways and tactile perception