MAGP2 controls Notch via interactions with RGD binding integrins: Identification of a novel ECM-integrin-Notch signaling axis

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MAGP2 controls Notch via interactions with RGD binding integrins: Identification of a novel ECM-integrin-Notch signaling axis

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作者：Peter Deford^b ; ¹ ; Kasey Brown^c ; Rae Lee Richards^c ; Aric King^c ; Kristin Newburn^c ; Katherine Westover^b ; Allan R. Albig^a ; ^b ; ^{AllanAlbig@boisestate.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：MAGP2 ; Microfibril associated glycoprotein 2 ; N1ICD ; Notch1 intracellular domain ; ECM ; Extracellular matrix ; HMEC ; Human microvascular endothelial cells.
刊名：Experimental Cell Research
出版年：2016
出版时间：1 February 2016
年：2016
卷：341
期：1
页码：84-91
全文大小：1244 K

文摘

•: A novel signaling mechanism between integrins and Notch is proposed.
•: ECM molecules MAGP2 and EGFL7 control Notch via RGD binding integrins.
•: Integrin–Notch signaling allows Notch to responds to cellular microenvironment.
•: Integrin–Notch signaling helps explain pro- and anti-Notch activity of MAGP2.

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