Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

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Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

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作者：Matthew R. Broadus¹ ; ² ; ⁹ ; Tony W. Chen¹ ; ⁹ ; Leif R. Neitzel¹ ; Victoria H. Ng¹ ; Jeanne N. Jodoin¹ ; ⁷ ; Laura A. Lee¹ ; Adrian Salic² ; David J. Robbins³ ; ⁴ ; Anthony J. Capobianco³ ; ⁴ ; James G. Patton⁵ ; Stacey S. Huppert⁶ ; ¹⁰ ; ^{stacey.huppert@cchmc.org" class="auth_mail" title="E-mail the corresponding author} ; Ethan Lee¹ ; ⁸ ; ¹⁰ ; ^{ethan.lee@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：31 May 2016
年：2016
卷：15
期：9
页码：1920-1929
全文大小：3357 K

文摘

•: A biochemical assay identifies the N1-Box degron of the Notch1 intracellular domain
•: Mutations in the Notch1 N1-Box promote signaling in human cells and zebrafish
•: The N1-Box functions independently of other known Notch1 degrons
•: Human cancer mutations within the N1-Box exhibit elevated Notch1 activity in vivo

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