Heat shock protein 70 (Hsp70) interacts with the Notch1 intracellular domain and contributes to the activity of Notch signaling in myelin-reactive CD4 T cells

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Heat shock protein 70 (Hsp70) interacts with the Notch1 intracellular domain and contributes to the activity of Notch signaling in myelin-reactive CD4 T cells

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作者：Maciej Jury艅czyk ; Przemys艂aw Lewkowicz ; Ma艂gorzata Domowicz ; Marcin P. Mycko ; Krzysztof W. Selmaj ; ^{kselmaj@afazja.am.lodz.pl" class="auth_mail" title="E-mail the corresponding author}
关键词：Hsp70 ; heat shock protein 70 ; MOG ; myelin oligodendrocyte protein ; NICD ; Notch intracellular domain
刊名：Journal of Neuroimmunology
出版年：2015
出版时间：15 October 2015
年：2015
卷：287
期：Complete
页码：19-26
全文大小：842 K

文摘

•: Hsp70 is required for the generation of Notch1 signaling in activated CD4 T cells.
•: Hsp70 directly interacts with activated form of Notch1 (NICD1) in CD4 T cells.
•: Hsp70-NICD1 interaction represents a novel mechanism regulating Notch signaling.

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