Do telomeres have a higher plasticity than thought? Results from the German Chronic Kidney Disease (GCKD) study as a high-risk population

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Do telomeres have a higher plasticity than thought? Results from the German Chronic Kidney Disease (GCKD) study as a high-risk population

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作者：Julia Raschenberger^a ; ¹ ; Barbara Kollerits^a ; ¹ ; Stephanie Titze^b ; Anna Kö ; ttgen^c ; Barbara Bä ; rthlein^d ; Arif B. Ekici^e ; Lukas Forer^a ; Sebastian Schö ; nherr^a ; Hansi Weissensteiner^a ; Margot Haun^a ; Christoph Wanner^f ; Kai-Uwe Eckardt^b ; Florian Kronenberg^a ; ^{Florian.Kronenberg@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author} ; for the GCKD study Investigators
关键词：Telomere length ; Kidney disease ; Telomerase activity ; Disease duration
刊名：Experimental Gerontology
出版年：2015
出版时间：December 2015
年：2015
卷：72
期：Complete
页码：162-166
全文大小：364 K

文摘

•: Relative telomere length (RTL) is considered as a biological marker for aging.
•: We investigated RTL in 4802 patients from the German Chronic Kidney Disease study.
•: We observed a U-shaped association of RTL with chronic kidney disease duration.
•: RTL was longer in patients with short and long versus intermediate disease duration.
•: Our data support a higher plasticity of RTL as until recently anticipated.

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