Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction

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Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction

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作者：Anne Forand¹ ; ² ; ⁶ ; ^{anne.forand@inovarion.com" class="auth_mail" title="E-mail the corresponding author} ; Eugé ; nie Koumakis¹ ; ³ ; Alice Rousseau¹ ; Yohann Sassier¹ ; Clé ; ment Journe⁴ ; Jean-Franç ; ois Merlin⁵ ; Christine Leroy¹ ; Valé ; rie Boitez¹ ; Patrice Codogno¹ ; Gé ; rard Friedlander¹ ; Isabelle Cohen¹
刊名：Cell Reports
出版年：2016
出版时间：6 September 2016
年：2016
卷：16
期：10
页码：2736-2748
全文大小：3009 K

文摘

•: Hepatocyte-specific Pit1-KO protects against HFD-induced obesity and diabetes
•: Pit1 deletion delayed an insulin negative feedback loop, sustaining insulin signaling
•: USP7 is a PiT1 binding partner
•: Pit1 deletion inhibited USP7/IRS1 dissociation upon insulin stimulation

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