Mercury(II) mediated cyclisation of R-1-(1′-hydroxyethyl)-2-(1″-propenyl)-3-alkoxy-4-methoxybenzenes to chiral isochromanes

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• 作者：de Koning ; Charles B. ; Giles ; Robin G.F. ; Green ; Ivan R. ; Jahed ; Nazeem M.
• 关键词：Isochromanes ; Mercury(II) acetate ; Quinones ; Oxidative cyclisation
• 刊名：Tetrahedron
• 出版年：2004
• 出版时间：March 8, 2004
• 年：2004
• 卷：60
• 期：11
• 页码：2629-2637
• 全文大小：245 K

文摘

A protocol has been established for the transformation of chiral ortho 1-hydroxyethyl propenyl benzenes under both anaerobic and oxidative mercury(II) mediated conditions to produce chiral isochromanes. Further transformations of the former products yielded chiral isochromanquinones, while the latter afforded the corresponding chiral 4-hydroxyisochromanquinones.