The synthesis of isochroman-4-ols and isochroman-3-ols: models for naturally occurring benzo[g]isochromanols

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• 作者：de Koning ; Charles B. ; Green ; Ivan R. ; Michael ; Joseph P. ; Oliveira ; José ; R.
• 关键词：isochromanols ; cyclization ; mercury and compounds ; oxygen
• 刊名：Tetrahedron
• 出版年：2001
• 出版时间：November 19, 2001
• 年：2001
• 卷：57
• 期：47
• 页码：9623-9634
• 全文大小：249 K

文摘

The synthesis of isochromanes containing hydroxy substituents at the 4- and 3-positions has been achieved. The key step for the synthesis of the isochroman-4-ols entailed an oxidative mercury mediated ring closure of 2-(prop-1-enyl)phenylmethanol derivatives, while in the synthesis of the isochroman-3-ols the key step involved ozonolysis of 2-(prop-2-enyl)phenylmethanol derivatives.