A mononuclear Ru(II) complex with meloxicam: DNA- and BSA-binding, molecular modeling and anticancer activity against human carcinoma cell lines

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A mononuclear Ru(II) complex with meloxicam: DNA- and BSA-binding, molecular modeling and anticancer activity against human carcinoma cell lines

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作者：Roya Esteghamat-Panah^a ; Hassan Hadadzadeh^a ; ^{hadad@cc.iut.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; Hossein Farrokhpour^a ; Maryam Mortazavi^a ; ^b ; Zahra Amirghofran^c
关键词：Ruthenium(II) complex ; Meloxicam ; DNA-binding ; BSA-binding ; Cytotoxicity ; Molecular docking
刊名：Inorganica Chimica Acta
出版年：2017
出版时间：1 January 2017
年：2017
卷：454
期：Complete
页码：184-196
全文大小：3014 K

文摘

•: Interaction of meloxicam and its Ru(II) complex with DNA and BSA.
•: The electrostatic or/and groove interactions of the Ru(II) complex with DNA.
•: A quite strong ability of both compounds to quench the fluorescence of BSA.
•: The cytotoxicity of both compounds against three cancer cell lines.
•: The molecular docking study of both compounds with DNA and BSA.

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