Metabolic Complications Precede Alloreactivity and Are Characterized by Changes in Suppression of Tumorigenicity 2 Signaling

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• 作者：Romany A.N. Johnpulle¹ ; Sophie Paczesny² ; Dae Kwang Jung¹ ; Etienne Daguindau² ; Madan H. Jagasia¹ ; Bipin N. Savani¹ ; Wichai Chinratanalab¹ ; Robert F. Cornell¹ ; Stacey Goodman¹ ; John P. Greer¹ ; Adetola A. Kassim¹ ; Salyka Sengsayadeth¹ ; Michael T. Byrne¹ ; Brian G. Engelhardt¹ ; ^{brian.engelhardt@vanderbilt.edu}
• 关键词：Post-transplantation diabetes mellitus ; Soluble suppression of tumorigenicity 2 ; sST2 ; Treatment-related mortality ; Metabolic complications ; IL-33 ; Allogeneic
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：23
• 期：3
• 页码：529-532
• 全文大小：325 K
• 卷排序：23

文摘

Post-transplantation diabetes mellitus occurs commonly after allogeneic transplantation Post-transplantation diabetes mellitus and acute graft-versus-host disease are affected by the IL-33/suppression of tumorigenicity 2 axis Elevated engraftment soluble suppression of tumorigenicity 2 predicts increased post-transplantation diabetes mellitus Elevated engraftment soluble suppression of tumorigenicity 2 predicts increased nonrelapse mortality risk