Jagged1 (JAG1): Structure, expression, and disease associations

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Jagged1 (JAG1): Structure, expression, and disease associations

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作者：Christopher M. Grochowski^a ; Kathleen M. Loomes^b ; ^c ; Nancy B. Spinner^a ; ^d ; ^{spinner@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：JAG1 ; Jagged1 ; NOTCH1 ; Notch1 ; NOTCH2 ; Notch2 ; ALGS ; Alagille syndrome ; TAN1 ; Translocation-Associated Notch Protein ; EGF ; Epidermal growth factor ; DSL ; Delta ; serrate and lag-2 ; GRC ; Genome reference consortium ; mRNA ; Messenger RNA ; PVM ; Portal vein mesenchyme ; CNC ; Cranial neural crest ; TOF ; Tetralogy of Fallot ; PS ; Pulmonic stenosis ; PPS ; Peripheral pulmonary stenosis
刊名：Gene
出版年：2016
出版时间：15 January 2016
年：2016
卷：576
期：1
页码：381-384
全文大小：305 K

文摘

•: Jagged1 is a cell surface ligand that functions in the Notch signaling pathway.
•: JAG1 mutations are responsible for Alagille syndrome and other disorders.
•: Expression and mouse models of Jag1 correlate with disease phenotypes.

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