The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase

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• 作者：Caezar Al-Jassar¹ ; ² ; Antonina Andreeva¹ ; ² ; Deepak D. Barnabas¹ ; Stephen H. McLaughlin¹ ; Christopher M. Johnson¹ ; Minmin Yu¹ ; Mark van Breugel¹ ; ³ ; ^{vanbreug@mrc-lmb.cam.ac.uk}
• 关键词：Cep104 ; TOG ; tubulin ; zinc finger ; Nek1 ; CP110 ; centriole ; basal body ; cilia
• 刊名：Structure
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：146-156
• 全文大小：3181 K
• 卷排序：25

文摘

The centriolar protein Cep104 contains a tubulin-binding TOG domain Nek1 kinase binds to a zinc finger array in Cep104 Nek1 and the centriole-capping protein CP110 compete for binding to Cep104 The Cep104's zinc finger array represents a novel arrangement of C2HC zinc fingers