Co-expression of tissue factor and IL-6 in immature endothelial cells of cerebral cavernous malformations

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• 作者：Shouhei Noshiro<sup>asup><sup> ; sup><sup>bsup> ; Takeshi Mikami<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>tmikami@sapmed.ac.jpsup> ; Yuko Kataoka-Sasaki<sup>bsup> ; Masanori Sasaki<sup>bsup><sup> ; sup><sup>dsup><sup> ; sup><sup>esup> ; Hirofumi Ohnishi<sup>csup> ; Shunya Ohtaki<sup>asup><sup> ; sup><sup>bsup> ; Masahiko Wanibuchi<sup>asup><sup> ; sup><sup>bsup> ; Nobuhiro Mikuni<sup>asup> ; Jeffery D. Kocsis<sup>dsup><sup> ; sup><sup>esup> ; Osamu Honmou<sup>bsup><sup> ; sup><sup>dsup><sup> ; sup><sup>esup>
• 关键词：Cerebral cavernous malformations ; Endothelial cell ; Tissue factor
• 刊名：Journal of Clinical Neuroscience
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：37
• 期：Complete
• 页码：83-90
• 全文大小：1923 K
• 卷排序：37

文摘

The expression of tissue factor (TF) and interleukin-6 (IL-6) in cerebral cavernous malformations (CCMs) was analyzed. The mRNA expression of TF of CCMs was significantly higher than that of the control. The mRNA expression of TF was correlated with the number of hemorrhage appearances and the mRNA expression level of IL-6. TF and both are present in the same immature endothelial cells. These factors may have a prognostic role in CCM.